Antioxidants in fruits and vegetables – the millennium’s health
Charanjit Kaur
Division of Fruits and Horticultural Technology, Indian Agricultural Research Institute, New Delhi-110012, India
Search for more papers by this authorCorresponding Author
Harish C. Kapoor
Division of Biochemistry, Indian Agricultural Research Institute, New Delhi-110012, India
*Correspondent: e-mail: [email protected]Search for more papers by this authorCharanjit Kaur
Division of Fruits and Horticultural Technology, Indian Agricultural Research Institute, New Delhi-110012, India
Search for more papers by this authorCorresponding Author
Harish C. Kapoor
Division of Biochemistry, Indian Agricultural Research Institute, New Delhi-110012, India
*Correspondent: e-mail: [email protected]Search for more papers by this authorAbstract
Some of the most exciting research in the last decade has been the discovery of a group of nutrients, which have protective effects against cell oxidation. These naturally occurring compounds impart bright colour to fruits and vegetables and act as antioxidants in the body by scavenging harmful free radicals, which are implicated in most degenerative diseases. Epidemiological studies have established a positive correlation between the intake of fruits and vegetables and prevention of diseases like atheroscelerosis, cancer, diabetes, arthritis and also ageing. So pronounced has been their effect on ageing that they have been called ‘fountains of youth’. Fruits and vegetables have thus had conferred on them the status of ‘functional foods’, capable of promoting good health and preventing or alleviating diseases. Phenolic flavonoids, lycopene, carotenoids and glucosinolates are among the most thoroughly studied antioxidants. The present review highlights the potential of fruits and vegetables rich in antioxidants, their health benefits and the effect of processing on the bioavailability of these nutrients. The paper also reviews some of the important methods used to determine the antioxidant activity.
References
- 1 Acheson, R.M. & Williams, D.R.R. (1983). Does consumption of fruits and vegetables protect against stroke. Lancer, 1, 1191–1193.
- 2 Alpha tocopherol, Beta carotene Cancer Prevention Study Group (ATBC) (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in the male smokers. New England Journal of Medicine, 330, 1029–1035.
- 3 Al-Saikhon, M.S., Howard, L.R., Miller, J.C. (1995). Antioxidant activity and total phenolics in different genotypes of potato (Solanum tuberosum). Journal of Food Science, 60, 341–343.
- 4 Amakura, Y., Umino, Y., Tsuji, S., Tonogai, Y. (2000). Influence of jam processing on the radical scavenging activity and phenolic content in berries. Journal of Agricultural Food Chemistry, 48, 6292–6297.
- 5 American Institute of Cancer Research. (1997). Food Nutrition, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute of Cancer Research.
- 6 Ames, B.N. (1983). Dietary carcinogens and anticarcinogens oxygen radicals and degenerative diseases. Science, 221, 1256–1262.
- 7 Ames, B.N., Shigenga, M.K., Hagen, T.M. (1993). Oxidants, antioxidants and degenerative diseases of ageing. Proceedings of National Academy of Sciences USA, 90, 7915–7922.
- 8 Ancos de, B., Gonzalez, E.M., Cano, M.P. (2000b). Ellagic acid, vitamin C and total phenolic contents and radical scavenging capacity affected by freezing and frozen storage in raspberry fruit. Journal of Agricultural Food Chemistry, 48, 4565–4570.
- 9 Ancos de, B., Ibanez, E., Reglero, G., Cano, M.P. (2000a). Frozen storage effects on anthocyanins and volatile compounds of raspberry fruit. Journal of Agricultural Food Chemistry, 48, 873–879.
- 10 Andlauer, W. & Furst, P. (1998). Antioxidative power of phytochemicals with special reference to cereals. Cereal Foods World, 43, 356–360.
- 11 Anese, M., Manzocco, L., Nicoli, M.C., Lerci, C.R. (1999). Antioxidant properties of tomato juice as affected by heating. Journal of the Science of Food and Agriculture, 79, 750–754.DOI: 10.1002/(sici)1097-0010(199904)79:5<750::aid-jsfa247>3.3.co;2-1
- 12 Anese, M., Pittia, P., Nicoli, M.C. (1993). Oxygen consuming properties of heated glucose-glycine aqueous solutions. Italian Journal of Food Science, 5, 75–79.
- 13 Appel, M.J. & Woutersen, R.A. (1996). Effects of dietary β-carotene and selenium on initiation and promotion of pancreatic carcinogenesis in azaserine treated rats. Carcinogenesis, 17, 1411–1416.
- 14 Arnaeo, M.B., Cano, A., Hernandez-Ruiz, J., Gracia Canovas, F., Acosta, M. (1996). Inhibition by L-ascorbic acid and other antioxidants of the 2-2′-azino-bis (3-ethyl-benzthiazoline-6-sulfonic acid) oxidation catalyzed by peroxidase: a new approach for determining total antioxidant status of foods. Analytical Biochemistry, 236, 255–261.DOI: 10.1006/abio.1996.0164
- 15 Ascherio, A., Rimm, E.B., Giovannicci, E.L. et al. (1992). A prospective study of nutritional factors and hypertension among US men. Circulation, 86, 1475–1484.
- 16 Baranowitz, S.A., Starrett, B., Brookner, A.R. (1996). Carotene deficiency in HIV patients. AIDS, 10, 115–118.
- 17 Benzie, I.E.F. & Strain, J.J. (1996). The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Analytical Biochemistry, 239, 70–76.DOI: 10.1006/abio.1996.0292
- 18 Bidlack, W.R. (1998). Phytochemicals: a potential new health paradigm. Food Technology, 52, 168–172.
- 19 Block, G., Patterson, B., Subar, A. (1992). Fruits, vegetables and cancer prevention: a review of the epidemiological evidence. Nutrition and Cancer, 18, 1–29.
- 20 Bocco, A., Cuvelier, M.E., Richard, H., Berset, C. (1998). Antioxidant activity and phenolic composition of citrus peel and seed extracts. Journal of Agricultural Food Chemistry, 46, 2123–2129.
- 21 Boileau, T.W.M., Moore, A.C., Erdman, J.W. (1999). Carotenoids and vitamin A. In: Antioxidant Status, Diet, Nutrition and Health (edited by A.M. Papas). Pp. 133–158. Boca Raton, FL: CRC Press.
- 22 Bonnely, S., Peyrat-Maillard, M.N., Rondini, L., Masy, D., Berset, C. (2000). Antioxidant activity of malt rootlet extracts. Journal of Agricultural Food Chemistry, 48, 2785–2792.
- 23 Bouic, P.J. & Lamprecht, J.H. (1999). Plant sterols and sterolins: a review of their immune-modulating properties. Altern Medical Review, 4, 170–179.
- 24 Bramley, P.M. (2000). Is lycopene beneficial to human health? Phytochemistry, 54, 233–236.DOI: 10.1016/s0031-9422(00)00103-5
- 25 Brand-Williams, W., Cuvelier, M.E., Berset, C. (1995). Use of a free radical method to evaluate antioxidant activity. Lebensm-Wiss Technology, 28, 25–30.
- 26 Bravo, I. (1998). Polyphenols: chemistry, dietary source, metabolism, and nutritional significance. Nutritional Review, 56, 317–333.
- 27 Bresnick, E., Birt, D.F., Woltuman, K., Wheeler, M.M., Markin, R.S. (1990). Reduction in mammary tumorogenesis in the rat by cabbage and cabbage residue. Carcinogenesis, 11, 1159–1163.
- 28 Bressa, F., Tesson, N., Dalla Rosa, M., Sensidoni, A., Yubaro, F. (1996). Antioxidant effect of Maillard reaction products: application to butter cookie of a competition kinetic analysis. Journal of Agricultural Food Chemistry, 44, 692–695.
- 29 Britton, G.W. (1995). Structure and properties of carotenoids in relation to function. FASB Journal, 9, 1551–1558.
- 30 Burning, J.E. & Hennekens, C.H. (1997). Antioxidant vitamin and cardiovascular diseases. Nutrition Review, 55, 553–560.
- 31 Calixeto, F.S. (1998). Antioxidant dietary fiber product: a new concept and a potential food ingredient. Journal of Agricultural Food Chemistry, 46, 4303–4306.
- 32 Cano, A., Hernandez-Ruiz, J., Garcia-Canovas, F., Acosta, M., Arnao, M.B. (1998). An end point method for estimation of the total antioxidant activity in plant material. Phytochemical Analysis, 9, 196–202.DOI: 10.1002/(sici)1099-1565(199807/08)9:4<196::aid-pca395>3.0.co;2-w
- 33 Cao, G., Booth, S.L., Sadowski, J.A., Prior, R.L. (1998). Increase in human plasma antioxidant capacity after consumption of controlled diets high in fruits and vegetables. American Journal of Clinical Nutrition, 68, 1081–1087.
- 34 Cao, G., Srfie, E., Prior, R.L. (1996). Antioxidant capacity of tea and common vegetables. Journal of Agricultural Food Chemistry, 44, 3425–3431.
- 35 Cao, G., Verdon, C.P., Wu, A.H.B., Wang, H., Prior, R.L. (1995). Automated oxygen radical absorbance capacity assay using COBAS FARA II. Clinical Chemistry, 41, 1735–1737.
- 36 Chandler, L.A. & Schwartz, S.J. (1987). HPLC separation of cis-trans carotene isomers in fresh and processed fruits and vegetables. Journal of Food Science, 52, 669–672.
- 37 Chu, Y.H., Chang, C.L., Hsu, H.F. (2000). Flavonoid content of several vegetables and their antioxidant activity. Journal of the Science of Food and Agriculture, 80, 561–566.DOI: 10.1002/(sici)1097-0010(200004)80:5<561::aid-jsfa574>3.3.co;2-r
- 38 Clarke, M.P. (1999). Can food forestall ageing. Agriculture Research USDA, February, 15–17.
- 39 Clinton, S.K. (1998). Lycopene chemistry, biology and implications for human health diseases. Nutrition Review, 56, 35–51.
- 40 Constantino, L., Albasino, A., Rastelli, G., Benvenuti, S. (1992). Activity of phenolic crude extract as scavenging of superoxide radicals and inhibitors of xanthine oxidase. Planta Medica, 58, 342–344.
- 41 Crowell, P.L. (1997). Monoterpenes in breast cancer chemoprevention. Breast Cancer Research Treatments, 46, 191–197.
- 42 Crozier, A., Lean, M.E.J., McDonald, M.S., Black, C. (1997). Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. Journal of Agricultural Food Chemistry, 45, 590–595.
- 43 Day, A.P. (1998). Effects of concentrated red grape juice consumption on serum antioxidant capacity and low density lipoprotein oxidation. Annals of Nutrition and Metabolism, 41, 353–355.
- 44 Deighton, N., Brennan, R., Finn, C., Davies, H.V. (2000). Antioxidant properties of domesticated and wild Rubus species. Journal of the Science of Food and Agriculture, 80, 107–1313.
- 45 Diaz, M.N., Frei, B., Vita, J.A., Keaney, J.F. (1997). Antioxidants and atherosclerotic heart disease. New England Journal of Medicine, 337, 408–416.
- 46 Dillard, C.J. & German, J.B. (2000). Phytochemicals: nutraceuticals and human health. Journal of the Science of Food and Agriculture, 80, 1744–1756.DOI: 10.1002/1097-0010(20000915)80:12<1744::aid-jsfa725>3.0.co;2-w
- 47 DiMasico, P., Kaiser, S., Sies, H. (1989). Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Archives of Biochemistry and Biophysics, 274, 532–538.
- 48 Djilas, S.M. & Milic, B.L. (1994.) Naturally occurring phenolic compounds as inhibitors of free radical formation in the Maillard Reaction. In: Maillard Reaction in Chemistry, Food and health (edited by T.P. Lakuja, G.A. Reineccius, V.M. Monnier, J. O’Brien & J.W. Beynes). Pp. 75–80. Cambridge: The Royal Society of Chemistry.
- 49 Doll, R. (1990). An overview of the epidemiological evidence linking diet and cancer. Proceedings of Nutrition Society, 49, 119–131.
- 50 Donovan, L.J., Meyer, A.S., Waterhouse, A.L. (1998). Phenolics composition and antioxidative activity of Prune and Prune Juice (Prunus domestica). Journal of Agricultural Food Chemistry, 46, 1247–1252.
- 51 Dragsted, C.O., Strube, M., Larsen, L.C. (1993). Cancer protective factors in fruits and vegetables. Biochemical and biological background. Pharmacology and Toxicology, 72(Suppl.), 116–135.
- 52 Duh, P.D., Yen, D.B., Yen, G.C. (1992). Extraction and identification of an antioxidative component from edible oils. Food Chemistry, 14, 45–51.
- 53 Dziezak, J.D. (1986). Preservaives., Antioxidants. The ultimate answer to oxidation. Food Technology, September, 94–102.
- 54 Eichner, K. (1981). Antioxidative effect of Maillard Reaction Intermediates. Progressive Food Nutrition Science, 5, 441–451.
- 55 Elliot, J.G. (1999). Application of antioxidant vitamins in foods and beverages. Food Technology, 53, 46–48.
- 56 Fahey, J.W. & Stephenson, K.K. (1999). Cancer chemoprotective effects of cruciferous vegetables. Horticulture Science, 34, 1159–1163.
- 57 Fogliano, V., Verde, V., Randazzo, G., Ritieni, A. (1999). Method of measuring antioxidant activity and its application to monitoring the antioxidants capacity of wines. Journal of Agricultural Food Chemistry, 47, 1035–1040.
- 58 Franceschi, S., Bicdoli, E., Veechia, C., Talamini, R., D'Avanzo, B., Negii, E. (1994). Tomatoes and risk of digestive tract cancers. International Journal of Cancer, 59, 181–184.
- 59 Frankel, E.N., Kanner, J., Germen, J.B., Perks, E., Kinsella, J.E. (1993). Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet, 341, 454–457.
- 60 Frankel, E.N., Waterhouse, A.L., Teissedre, P. (1995). Principal phenolic phytochemicals in selected California wines and their antioxidant activity in inhibiting oxidation of human low density lipoproteins. Journal of Agricultural Food Chemistry, 43, 890–894.
- 61 Fuhrman, B., Lavy, A., Aviram, M. (1995). Consumption of red wines with meals reduces the susceptibility of human plasma and low density lipoproteins to lipid peroxidation. American Journal of Chemical Nutrition, 61, 549–554.
- 62 Garcia-Closas, R., Gonzalez, C.A., Agudo, A., Riboli, E. (1999). Intake of specific carotenoids and flavonoids and the risk of gastric cancer in Spain. Cancer Causes and Control, 10, 71–75.DOI: 10.1023/a:1008867108960
- 63 Gaulejac, N., Glories, Y., Vivas, N. (1999b). Free radical scavenging effect of anthocyanins in red wines. Food Research International, 32, 37–333.
- 64 Gaulejac, N., Vivas, N., Borgeois, G. (1999a). The influence of various phenolics compounds on scavenging activity assessed by an enzymatic method. Journal of the Science of Food and Agriculture, 79, 1081–1090.DOI: 10.1002/(sici)1097-0010(199906)79:8<1081::aid-jsfa330>3.3.co;2-7
- 65 Gazzani, G., Papetti, A., Massolini, G., Daglia, M. (1998). Antioxidative and pro-oxidant activity of water soluble components of some common diet vegetables and the effect of thermal treatment. Journal of Food Chemistry, 6, 4118–4122.
- 66 Gerster, H. (1997). The potential role of lycopene for human health. Journal of American Clinical Nutrition, 16, 109–126.
- 67 Gey, K.F., Puska, P., Jordan, P., Moser, V.K. (1991). Inverse correlation between plasma vitamin E and mortality for ischemic heart disease in cross-cultured epidemiology. American Journal of Clinical Nutrition, 53, 326C–334S.
- 68 Gil, M.I., Ferreres, F., Tomas-Barberan, F.A. (1999). Effect of post harvest storage and processing on the antioxidant constituents (flavonoids and vitamin C) of fresh cut spinach. Journal of Agricultural Food Chemistry, 47, 2213–2217.
- 69 Gil, M.I., Tomas-Barberan, F.A., Hess- Pierce, B., Holeroft, D.M., Kader, A.A. (2000). Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. Journal of Agricultural Food Chemistry, 48, 4581–4589.
- 70 Giovannucci, E. (1999). Tomatoes, tomato-based products, lycopene and cancer: Review of epidemiolgic literature. Journal of National Cancer Institute, 91, 317–331.
- 71 Giovanucci, E., Asherio, A., Willett, W.C. (1995). Intake of carotenoids and retinol in relation to the risk of prostate cancer. Journal of National Cancer Institute, 87, 1767–1776.
- 72
Glazer, A.N. (1990). Phycoerythrin fluorescence-based assay of reactive oxygen species.
Methods in Enzymology, 186, 167–168.
10.1016/0076-6879(90)86106-6 Google Scholar
- 73 Gould, M.N. (1997). Cancer chemoprevention and therapy by monoterpenes. Environment Health Perspective, 105, 977–979.
- 74 Greefield, H. & Southgate, D.A.T. (1992). Food Composition Data Production, Management and Use. Elsevier Applied Science.
- 75 Greenberg, E.R., Baron, J.A., Tosteson, T.D. et al. (1994). A clinical trial of antioxidant vitamin to prevent colorectal cancer. New England Journal of Medicine, 331, 141–147.
- 76 Guo, C., Cao, G., Sofic, E., Prior, R.L. (1997). High performance liquid chromatography coupled with colorometric array detection of electroactive components on fruits and vegetables: relationship to oxygen radical absorbance capacity. Journal of Agricultural Food Chenistry, 45, 1787–1796.
- 77 Hagerman, A.E., Riedl, K.M., Jones, G.A. et al. (1998). High molecular weight plant polyphenolics (tannins) as biological antioxidants. Journal of Agricultural Food Chemistry, 46, 1887–1892.
- 78 Hakkinen, S.H., Karenlampi, S.O., Mykkanen, H.M., Torronen, A.R. (2000). Influence of domestic processing and storage on flavonol contents in berries. Journal of Agricultural Food Chemistry, 48, 2960–2965.
- 79 Halliwell, B., Gutteridge, J.M.C., Aruoma, O.I. (1987). The deoxy ribose method: a simple test tube assay for determination of rate constants for reaction of hydroxyl radicals. Analytical Biochemistry, 165, 215–219.
- 80 Halliwell, B., Murcia, M.A., Chirico, S., Auroma, O.I. (1995). Free radicals and antioxidants in food and in vivo: what they do and how they work?. Critical Review in Food Science and Nutrition, 35, 7–20.
- 81 Hammerschmidt, P.A. & Pratt, D.E. (1978). Phenolic antioxidants of dried soybeans. Journal of Food Science, 43, 556–559.
- 82 Hara, H., Haga, S., Aoyama, Y., Kiriyama, S. (1999). Short chain fatty acids supress cholestrol synthesis in rat liver and intestine. Journal of Nutrition, 129, 942–948.
- 83 Heinonen, M., Lehtonen, P.J., Hopia, A. (1998a). Antioxidative activity of berry and fruit wines and liquor. Journal of Agricultural Food Chemistry, 46, 25–31.
- 84 Heinonen, I.M., Meyer, A.S., Frankel, E.N. (1998b). Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation. Journal of Agricultural Food Chemistry, 46, 4107–4122.
- 85 Hennekens, C.H., Buring, J.E., Peto, R. (1994). Antioxidant vitamins: Benefits not yet proved. New England Journal of Medicine, 330, 1080–1081.
- 86 Hennekens, C.H., Buring, J.E., Manson, M. et al. (1996). Lack of effect of long term supplementation with β-carotene on the incidence of malignant neoplasms and cardiovascular disease. New England Journal of Medicine, 334, 1145–1149.
- 87 Hertog, M.G.L., Feskens, E.J.M., Hollman, P.C.H., Katan, J.B., Kromhout, D. (1993). Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet, 342, 1007–1011.
- 88 Hertog, M.G.L., Hollman, P.C.H., Katan, M.B. (1992). Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in The Netherlands. Journal of Agricultural Food Chemistry, 40, 2379–2383.
- 89 Hirasa, K. & Takemasa, M. (1998). Spice Science Tecnology. New York: Marcel Dekker.
- 90 Hirayama, O., Nakamina, K., Hamada, S., Koliayashi, Y. (1994). Singlet oxygen quenching ability of naturally occurring carotenoids. Lipids, 29, 149–150.
- 91 Hirota, S., Shimoda, T., Takahama, U. (1998). Tissue and spatial distribution of flavonol and peroxidase in onion bulbs and stability of flavanolglucosides during boiling of the scales. Journal of Agricultural Food Chemistry, 46, 3497–3502.
- 92 Hopia, A., Huang, S.W., German, B.J., Frankel, E.N. (1996). Effect of different lipid systems on antioxidant activity of rosemary constituents camasol and carnosic acid with and without alpha-tocopherol. Journal of Agricultural Food Chemistry, 44, 2030–2036.
- 93 Hopia, A.I. & Heinonen, M. (1999). Comparison of antioxidant activity of flavonoid aglycons and their glycosides in methyl linoleate. Journal of American Oil Chemist Society, 76, 139–144.
- 94 Howard, L.A., Wong, A.D., Perry, A.K., Klein, B.P. (1999). β-Carotene and ascorbic acid in fresh and processed vegetables. Journal of Food Science, 64, 929–936.
- 95 Huang, M.T. & Ferraro, T. (1991). Phenolic compounds in food and cancer prevention. In: Phenolic Compounds in Food and Their Effects on Health: Antioxidants and Cancer Prevention (edited by M.T. Huang, C.-T. Ho & C.Y. Lee). Pp. 220–238. ACS Symposium Series 5078. Washington, DC: American Chemical Society.
- 96 Iwai, K., Abe, K., Matsue, H. (2000). Establishment of XYZ-dish method for a new antioxidative activity assay using photon detection. Nippon Shokuhin Kagaku Kogaku Kaishi, 47, 181–190.
- 97 Jones, P.H.J., Nitanios, F.Y., Raeini-Saraz, M., Vanstone, C.A. (1999). Cholestrol lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in a hyperlipidemic men. American Journal of Clinical Nutrition, 69, 1144–1150.
- 98 Jonsson, I. (1991). Thermal degradation of carotenoids and influence of their physiological functions. In: Nutrition and Toxicologycal Consequences of Food Processing (edited by M. Friedman). Pp. 75–82. New York, NY, USA: Plenum Press.
- 99 Joseph, J.A., Shukit-Hale, B., Denisova, N.A. et al. (1999). Reversal of age-related declines in neuronal signal transduction, cognitive, and motor behavioural deficits with blue berry, spinach, or strawberry dietary supplementation. Journal of Neuroscience, 19, 8114–8812.
- 100 Justesen, U., Knuthsen, P., Leth, T. (1998). Quantitative analysis of flavanols, flavones, and flavanones in fruits, vegetables and beverages by high performance liquid chromatography with photodiode array and mass spectrometric detection. Journal of Chromatography, 799, 101–110.
- 101 Kaanane, A., Kane, D., Labuza, T.P. (1988). Time and temperature effect on stability of Moroccan processed orange juice during storage. Journal of Food Science, 53, 1470–1489.
- 102 Kahkonen, M.P., Hopia, A.I., Vuorela, H.J. et al. (1999). Antioxidant activity of plant extracts containing phenolic compounds. Journal of Agricultural Food Chemistry, 47, 3954–3962.
- 103 Kanner, J., Frankel, E., Granit, R. et al. (1994). Natural antioxidants in grapes and wines. Journal of Agricultural Food Chemistry, 42, 64–69.
- 104 Karakaya, S. & Kavas, A. (1999). Antimutagenic activities of some foods. Journal of Agricultural Food Chemistry, 79, 237–242.
- 105 Khachik, F., Beecher, G.R., Smith, J.C. (1995). Lutein, lycopene and their oxidative metabolites in chemoprevention of cancer. Journal of Cell Biochemistry, Suppl., 22, 236–246.
- 106 Khachik, F., Goli, M.B., Beecher, G.R. et al. (1992). Effect of food preparation on qualitative and quantitative distribution of major carotenoids constituents of tomatoes and several green vegetables. Journal of Agricultural Food Chemistry, 40, 390–398.
- 107 Kikugava, K., Kunugi, A., Kurechi, T. (1990). Natural antioxidants exploited commercially. In: Food Antioxidants (edited by B.J.F. Hudson). Pp. 65–98. Essex: Elsevier Applied Science.
- 108 Kikuzaki, H. & Nakatani, N. (1993). Antioxidant effects of some ginger constituents. Journal of Food Science, 58, 1407–1410.
- 109 Kinsella, J.E., Frankel, E., German, B., Kanner, J. (1993). Possible mechanism and protective role of antioxidants in wine and plant foods. Food Technology, 47, 85–89.
- 110 Klein, B.P. & Kurilich, A.C. (2000). Processing effects on dietary antioxidants from plant foods. Horticulture Science, 35, 580–584.
- 111 Knekt, P., Jarvinen, R., Seppanen, R., Heliovaara, M., Teppo, L., Aroma, A. (1997). Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. American Journal of Epidemiology, 146, 223–230.
- 112 Kohlmeier, L. & Hastings, S.B. (1995). Epidemiologic evidence of a role of carotenoid in cardiovascular disease prevention. American Journal of Clinical Nutrition, 62, S1370–S1376.
- 113 Kohlmeier, L., Clark, J.D., Gomez-Gracia, E. et al. (1997). Lycopene and myocardial infection risk in the EURAMIC study. American Journal of Epidemiology, 146, 618–626.
- 114 Lansky, E., Shubert, S., Neeman, I. (1998). Pharmacological and therapeutical properties of pomegranate. In: Proceedings Ist International Symposium on Pomegranate (edited by P. Megarazo, J.J. Martinez & J. Martinez.). pp. Pr-07. Orihuela, Spain: CIHEAM.
- 115 Larrauri, J.A., Ruperez, P., Saura-Calixeto, F. (1997). Effect of drying temperature on the stability of polyphenols and antioxidant activity of red grape pomace peels. Journal of Agricultural Food Chemistry, 45, 1890–1893.
- 116 Lathrop, P.J. & Leung, H.K. (1980). Rate of ascorbic acid degradation during thermal processing of canned peas. Journal of Food Science, 45, 152–153.
- 117 Lavelli, V., Peri, C., Rizzolo, A. (2000). Antioxidant activity of tomato products as studied by model reactions using xanthine oxidase, myeloperoxidase, and copper-induced lipid peroxidation. Journal of Agricultural Food Chemistry, 48, 1442–1448.
- 118 Lee, H.S. (1992). Antioxidant activity of browning reaction products isolated from storage aged orange juice. Journal of Agricultural Food Chemistry, 40, 550–552.
- 119 Lee, I.M., Cook, C., Rosner, N.R., Manson, M., Buring, J.E., Hennekens, C.H. (1999). Beta-carotene supplementation and incidence of cancer and cardiovascular disease: The women’s health study. Journal of the National Cancer Institute, 91, 2102–2106.DOI: 10.1093/jnci/91.24.2102
- 120 Levy, J., Bosin, E., Fieldman, B. et al. (1995). Lycopene is a more potent inhibitor of human cancer cell proliferation than either α-carotene or β-carotene. Nutritional Cancer, 24, 257–266.
- 121 Lietty, A., Cristoni, A., Picci, M. (1976). Studies on Vaccinium myrtillus anthocyanosides: Vasoprotective and antiinflammatory activity. Arzneim-Forch, 26, 829–832.
- 122 Liu, R.H. (2000). Cancer- An apple a day helps keep cancer away. Nature, 405, 903–904.DOI: 10.1038/35016148
- 123 Lund, D.B. (1979). Effects of commercial processing on nutrients. Food Technology, 33, 28–34.
- 124 Macheix, J.J., Fleuriet, A., Billot, J. (1990). Fruit Phenolics. Boca Raton, FL: CRC Press.
- 125 Maeda, H., Katsuki, T., Akaiki, T., Yasutake, R. (1992). High correlation between lipid peroxide radical and tumor promotor effect: supression of the tumor production in the Epstein-Barr virus/B-lymphocytes system and scavenging of alkyl peroxide radicals by various vegetable extracts. Japanese Journal of Cancer Research, 83, 923–928.
- 126 Matasufuji, H., Nakamuro, H., Chino, M., Mitsuharo, T. (1998). Antioxidant activity of capasanthin and the fatty acid esters in paprika (Capsicum annum). Journal of Agricultural Food Chemistry, 46, 3468–3472.
- 127 Matasushima-Nishikawa, R., Shidoji, Y., Nishiwaki, S., Yamada, T., Moriwaki, H., Muto, Y. (1995). Supression by carotenoids of microcystin-induced morphological changes in mouse hepatocytes. Lipids, 30, 1029–1034.
- 128 McCarthy, M.A. & Mattehus, R.H. (1994). Nutritional quality of fruits and vegetables subjected to minimal processes. In: Minimally Processed Refrigerated Fruits and Vegetables (edited by R.C. Wiley). Pp. 313–326. New York: Chapman & Hall.
- 129 Meltzer, H.M. & Malterud, K.E. (1997). Can dietary flavonoids influence the development of coronary heart disease?. Scandavian Journal of Nutrition, 41, 50–57.
- 130 Meyer, A.S., Donovan, J.L., Pearson, D.A., Waterhouse, A.I., Frankel, E.N. (1998b). Fruit hydroxycinnamic acids inhibit human low-density lipoproteins oxidation in vitro. Journal of Agricultural Food Chemistry, 46, 1783–1787.
- 131 Meyer, A.S., Jepsen, S.M., Nina, S.S. (1998a). Enzymatic release of antioxidants for human low density lipoprotein from grape pomace. Journal of Agricultural Food Chemistry, 46, 2439–2446.
- 132 Meyer, A.S., Yi, O.-S., Pearson, D.A., Waterhouse, A.I., Frankel, E.N. (1997). Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes. Journal of Agricultural Food Chemistry, 45, 1638–1643.
- 133 Miki, N. & Akatsu, K. (1971). Stability in tomato juice of lycopene from inner and outer part of the flesh. Nippon Journal of Food Science and Technology, 18, 309–312.
- 134 Miki, W. (1991). Biological functions and activities of animal carotenoids. Pure Applied Chemistry, 63, 141–146.
- 135 Miller, N.J., Diplock, A.T., Rice Evans, C.A. (1995). Evaluation of the total antioxidant activity as a marker of apple juice on storage. Journal of Agricultural Food Chemistry, 43, 1794–1801.
- 136 Miller, N.J., Rice-Evans, C.A., Davies, M.J., Gopinathan, V., Milner, A. (1993). A novel method of measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates. Clinical Science, 84, 407–412.
- 137 Mimaki, Y., Kuroda, M., Kameyama, A., Yokosuka, A., Sahida, Y. (1998). Steriodal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL60 cells. Phytochemistry, 48, 485–493.DOI: 10.1016/s0031-9422(98)00036-3
- 138 Mitimura, T., Tsundo, S., Nagasawa, H. (1996). Lycopene, a carotenoid, supresses TGF alpha mRNA expression in spontaneous mammary tumors of SHN mice. Bulletin Faculty of Agriculture, Meiji University, 105, 45–48.
- 139 Mitsuda, H., Yasumoto, K., Iwami, K. (1966). Antioxidant action of indole compounds during the auto-oxidation of linoleic acid. Eiyo to Shekyuryou, 19, 210–214.
- 140 Miyake, T. & Shibamoto, T. (1997). Antioxidative activities of Natural compounds found in plants. Journal of Agricultural Food Chemistry, 45, 1819–1822.
- 141 Moriguchi, S., Okshima, N., Sumida, S., Okamura, K., Kishino, Y. (1996). β-Carotene supplementation enhances lymphocyte proliferation with mutagens in human peripheral blood lymphocytes. Nutrition Research, 16, 211–212.DOI: 10.1016/0271-5317(96)00005-x
- 142 Mortensen, A. & Skibsted, L.H. (1997). Importance of carotenoid structure in radical scavenging reactions. Journal of Agricultural Food Chemistry, 45, 2970–2977.
- 143 Nagasawa, H., Mitamura, T., Sakamoto, S., Yamamoto, K. (1995). Effect of lycopene on spontaneous mammary tumor development in SHN virgin mice. Anticancer Research, 15, 1173–1178.
- 144 Nakatani, N. (1997). Antioxidants from spices and herbs. In: Natural Antioxidants: Chemistry, Health, Effects and Applications (edited by F. Shahidi). Pp. 64–75. Champaign, IL: AOAC Press.
- 145 Namiki, M. (1990). Antioxidants/antimutagens in food. Critical Review in Food Science and Nutrition, 29, 273–300.
- 146 Narisawa, T., Fukaura, Y., Hasebe, M. et al. (1996). Inhibtory effects of natural carotenoids, α-carotene, lycopene and lutein, on colonic aberrant crypt foci formation in rats. Cancer Letters, 107, 137–142.DOI: 10.1016/0304-3835(96)04354-6
- 147 Newmark, H., Mergens, W., Newmark, H.L. (1984). A hypothesis for dietary components as blocking agents of chemical carcinogenesis: Plant phenolics and pyrrole pigments. Nutrition and Cancer, 6, 58–70.
- 148 Nicoli, M.C., Anese, M., Parpinel, M. (1999). Influence of processing on the antioxidant properties of fruits and vegetables. Trends in Food Science Technology, 10, 94–100.DOI: 10.1016/s0924-2244(99)00023-0
- 149 Nicoli, M.C., Anese, M., Parpinel, M.T., Franceschi, S., Lerici, C.R. (1997). Study on loss and formation of antioxidants during processing and storage. Cancer Letters, 114, 71–74.DOI: 10.1016/s0304-3835(97)04628-4
- 150 Nishina, A., Kuboto, K., Kameoka, H., Osawa, T. (1991). Anti Oxidizing Component, Musizin, in Rumex japonicus. Houtt. Journal American Oil Chemists Society, 68, 735–739.
- 151 Ojima, F., Sakamoto, H., Ishiguro, Y., Terao, J. (1993). Consumption of carotenoids in photosensitized oxidation of human plasma and plasma low density lipoproteins. Free Radicals in Biology and Medicine, 15, 377–384.
- 152 Okuda, T., Yoshida, T., Hatano, T. (1992). Antioxidant effects of tannins and related phenols. In: Phenolic Compounds in foods and their effect on health (edited by M.T. Huang, C.T. Ho & C.Y. Lee). Pp. 87–97. Washington, DC: American Chemical Society.
- 153 Omenn, G.S., Goodman, G.E., Thornquist, M.D. et al. (1996). Effects of combination of beta-carotene and vitamin A on lung cancer and cardiovascular diseases. New England Journal of Medicine, 334, 1150–1155.
- 154 Oomah, B.D. & Mazza, G. (2000). Functional Foods. In: The Wiley Encyclopedia of Science & Technology, 2nd edition, V2 (edited by F.J. Francis). Pp. 1176–1182. New York, NY: Wiley.
- 155 Papas, A.M. (1999). Vitamin E: tocopherols and tocotrienols. In: Antioxidant Status, Diet, Nutrition and Health (edited by A.M. Papas). Pp. 189–210. Boca Raton, FL: CRC Press.
- 156 Parfitt, V.J., Rubba, P., Bolton, C., Marotta, G., Hartog, M., Mancini, M. (1994). A comparison of antioxidant status and free radical peroxidation of plasma lipoprpteins in the healthy young persons from Naples and Bristol. European Heart Journal, 15, 871–876.
- 157 Piironen, G.W., Price, K.R., Rhodes, M.J.C., Williamsons, G. (1986). Tocopherols and tocotrienols in Finnish foods: Vegetables, fruits and berries. Journal of Agricultural Food Chemistry, 34, 742–746.
- 158 Pool-Zobel, B.L., Bub, A., Muller, H., Wollowski, I., Hochkemmet, G. (1997). Consumption of vegetables reduces genetic damage in humans: First result of a human intervention trial with carotenoid-rich foods. Carcinogenesis, 18, 1847–1850.DOI: 10.1093/carcin/18.9.1847
- 159 Porter, L.W., Levasseur, L.A., Henick, A.S. (1977). Evaluation of some natural and synthetic antioxidants in linoleic acid monolayer on silica. Journal of Food Science, 42, 1533–1535.
- 160 Potischman, N., Hoover, R.N., Brinton, L.A. et al. (1994). The relation between cervical cancer and serological markers of nutritional status. Nutrition and Cancer, 21, 193–201.
- 161 Price, K.R., Bacon, J.R., Rhodes, M.J.C. (1997). Effect of storage and domestic processing on the content and composition of flavanol glucosides in onion (Allium). Journal of Agricultural Food Chemistry, 45, 938–942.
- 162 Price, K.R., Casuscelli, F., Colquhoun, I.J., Rhodes, M.J.C. (1998a). Composition and content of flavonolglycosides in broccoli florets (Brassica olearacea) and their fate during cooking. Journal of Science of Food and Agriculture, 77, 468–472.
- 163 Price, K.R., Colquhoun, I.J., Barnes, K.A., Rhodes, M.J.C. (1998b). Composition and content of flavonol glycosides in green beans and their fate during processing. Journal of Agricultural Food Chemistry, 46, 4898–4903.
- 164 Price, K.R., Prosser, T., Richetin, A.M.F., Rhodes, M.J.C. (1999). A comparison of the flavonol content and composition in desert, cooking, and cider making apples; distribution within the fruit and effect of juicing. Food Chemistry, 66, 489–494.DOI: 10.1016/s0308-8146(99)00099-0
- 165 Prieme, H., Loft, S., Nyyssonen, K., Salonen, J.T., Poulsen, H.E. (1997). No effect of supplementation with vit. E, ascorbic acid or coenzyme Q10 on oxidative damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosine excretion in smokers. American Jounal of Clinical Nutrition, 65, 503–507.
- 166 Prior, R.L. & Cao, G. (2000). Antioxidant phytochemicals in fruits and vegetables: diet and health implications. Horticulture Science, 35, 588–592.
- 167 Prior, R.L., Cao, G., Martin, A. et al. (1998). Antioxidant capacity as influenced by total phenolics and anthocyanin content, maturity and variety of Vaccinium species. Journal of Agricultural Food Chemistry, 46, 2686–2693.
- 168
Ramon, J.M.,
Serra, L.,
Cerdo, C.,
Oromi, J. (1993). Dietary factors and gastric cancer risk.
Cancer, 71, 1731–1735.
10.1002/1097-0142(19930301)71:5<1731::AID-CNCR2820710505>3.0.CO;2-X CASPubMedWeb of Science®Google Scholar
- 169 Rapola, J.M., Virtamo, J., Rippati, S. et al. (1997). Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infection. Lancet, 349, 1715–1720.
- 170 Rechner, A. (2000). Einfluss der verarbeitungstechnik auf die antioxidative kapazitat von wertgebenden apfel- und beerensaftkomponenten. Dissertation, Universitat GieBen.
- 171 Renaud, S. & De Lorgeril, M. (1992). Wine, alcohol, platelets and the French Paradox for coronary heart disease. Lancet, 339, 1523–1526.
- 172 Rice-Evans, C.A. & Miller, N.T. (1994). Total antioxidant status in plasma and blood fluids. Methods in Enzymology, 234, 279–293.
- 173 Rice-Evans, C.A., Miller, N.T., Paganga, G. (1997). Antioxidant properties of phenolic compounds. Trends in Plant Science, 4, 304–309.
- 174 Salah, N., Miller, N.J., Paganga, G., Tijburg, L., Bolwell, P., Rice-Evans, C. (1995). Polyphenolic flavonoids as scavengers of aqueous phase radicals and as chain breaking antioxidants. Archives in Biochemistry and Biophysics, 322, 339–346.
- 175 Salvini, S., Parpinel, M., Gnagnarella, P., Maisonneuve, P., Turrini, A. (1998). Banca Dati Di Composizione Degil Alimenti Per Studi Epidemiologici in Italia. Milano: Instituto Europeo di Oncologia.
- 176 Scalfi, L., Fogliano, V., Pentangelo, A., Graziani, G., Giordano, I., Ritieni, A. (2000). Antioxidant activity and general fruit characteristics in different ecotypes of Corbarini small tomatoes. Journal of Agricultural Food Chemistry, 48, 1363–1366.
- 177 Schmidt, D.R. & Sobota, A.E. (1998). An examination of the antiadherence activity of cranberry and low-density lipoprotein oxidation. Annals of Nutrition Metabolism, 41, 353–357.
- 178 Schubert, S.Y., Lansky, E.P., Neeman, I. (1999). Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. Journal of Ethnopharmacology, 66, 11–17.DOI: 10.1016/s0378-8741(98)00222-0
- 179 Severini, C. & Pittia, P. et al. (1994). Interaction between Maillard reaction products and lipid oxidation during the roasting process and storage of hazel nuts. In: Development in Food Engineering (edited by T. Yano, R. Matsuno & K. Nakamura). Pp. 289–291. Glasgow, UK: Blackie Academic and Professional Press.
- 180 Shahidi, F. & Wanasundam, P.K.J. (1992). Phenolic antioxidants. Critical Review in Food Science and Nutrition, 32, 67–103.
- 181 Singleton, V.L. (1982). Grape and wine phenolics: Background and prospectus. In: Proceedings University California, Davis, Wine Grape Centennial Symposium (edited by A.D. Webb). Davis: Department Viticulture and Enology, University of California.
- 182 Smith, W., Mitchell, P., Webb, K., Leider, S.R. (1999). Dietary oxidants and age-related maculopathy: The blue mountain study. Opthamology, 106, 761–767.
- 183 Smith, J.G., Yokoyama, W.H., German, G.B. (1998). Butyric acid from diet: actions at the levels of gene expression. Critical Review of Food Science, 38, 259–267.
- 184 Southon, S. (1998). Increased consumption of fruits and vegetables in the prevention of cancer of the colon, rectum and breast. Epidemiology, 9, 338–341.
- 185 Southon, S. (2000). Increased fruit and vegetable consumption within the EU: Potential health benefits. Food Research International, 33, 211–217.DOI: 10.1016/s0963-9969(00)00036-3
- 186 Stahelin, H.B., Gey, K.F., Eichholzer, M., Ludin, E. (1991). β-carotene and cancer prevention: The basal study. American Journal of Clinical Nutrition, 53, 265S–269S.
- 187 Stampfer, M.J., Hennekens, C.H., Manson, J.E., Colditz, G.A., Rosner, B., Willett, W.C. (1993). Vitamin consumption and the risk of coronary disease in women. New England Journal of Medicine, 328, 1444–1449.
- 188 Steinberg, D. (1991). Antioxidants and atherosclerosis. A current assessment. Circulation, 84, 1420–1425.
- 189 Steinmetz, K.A. & Potter, J.D. (1996). Vegetable, fruit and cancer epidemiology. Cancer Causes and Control, 2, 325–351.
- 190 Strube, M., Haenen, G.R.M., Van Den Berg, H., Bast, A. (1997). Pitfalls in a method for assessment of total antioxidant capacity. Free Radical Research, 26, 515–521.
- 191 Suh, H.J., Lee, J.M., Cho, J.S., Kim, Y.S., Chung, S.H. (1999). Radical scavenging compounds in onion skin. Food Research International, 32, 659–664.DOI: 10.1016/s0963-9969(99)00141-6
- 192 Taga, M.S., Miller, E.E., Pratt, E. (1984). Chia seed natural antioxidants. Journal of Association of Oil Chemists Society, 61, 928–931.
- 193 Talalay, P. (1992). The role of enzyme induction in protection against carcinogenesis. In: Cancer Chemoprevention (edited by L. Wattenberg, M. Lipkin, G.W. Boone & G.J. Kelloff). Pp. 469–478. Boca Raton, FL: CRC Press.
- 194 Talcott, S.T., Howard, L.R., Brenes, C.H. (2000). Antioxidant changes and sensory properties of carrot puree processed with and without periderm tissues. Journal of Agricultural Food Chemistry, 48, 1315–1321.
- 195 Teel, R.W. & Castonguay, A. (1992). Antimutagenic effects of polyphenolic compounds. Cancer Letters, 66, 107–113.
- 196 Teissedre, P.L., Frankel, E.N., Waterhouse, A.L., Peleg, E., Germen, J.B. (1996). Inhibition of in vitro human LDL oxidase by phenolic antioxidants from grapes and wines. Journal of the Science of Food and Agriculture, 70, 55–61.DOI: 10.1002/(sici)1097-0010(199601)70:1<55::aid-jsfa471>3.0.co;2-x
- 197 Torronen, R. (2000). Flavonols and ellagic acid in berries. Recent Advances in Agricultural and Food Chemistry, 1, 31–37.
- 198 Tribble, D.L. (1999). Antioxidant consumption and risk of coronary heart diseases. Emphasis on vitamin C, vitamin E and beta carotene. Circulation, 99, 591–595.
- 199 Tubaro, F. & Ursini, F. (1996). Misura Dell′ Attivita Antiossidante Tramite L’analisi Di Una Cineticadi Competizione in Antiossidanti Naturali Negli Alimenti Aspetti Technologici E Qualitativi (edited by I. Conte, M. Dalla, Rosa & A. Zamarani). Pp. 45–53. Padova: CLEUP.
- 200 Uedo, N., Tatasuta, M., Iushi, H. et al. (1999). Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N-nitro-N-nitrosoguanidine in Wistar rats. Cancer Letters, 137, 131–136.DOI: 10.1016/s0304-3835(98)00340-1
- 201 Unno, T., Sugimoto, A., Kakuda, T. (2000). Scavenging effect of tea catichins and their epimers on superoxide anion radicals generated by hypoxanthine-xanthine oxidase system. Journal of the Science of Food and Agriculture, 80, 601–606.DOI: 10.1002/(sici)1097-0010(200004)80:5<601::aid-jsfa581>3.3.co;2-f
- 202 Usman, A. & Hosono, A. (1997). Antimutagenic activity of Maillard reaction Products against mutagenic heated Tauco. Italian Journal of Food Science, 9, 267–276.
- 203 Van Den Berg, R.V., Haenen, G.R.M.M., Van Den Berg, H., Bast, A. (1999). Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures. Food Chemistry, 66, 511–517.DOI: 10.1016/s0308-8146(99)00089-8
- 204 Van den Broeck, L., Ludikhuyeze, L., Weemaes, C., Van Loey, M. (1998). Kinetics for isobaric-isothermal degradation of L-ascorbic acid. Journal of Agricultural Food Chemistry, 46, 2001–2006.
- 205 Van Poppel, G. (1993). Carotenoids and cancer: An update with emphasis on human intervention studies. European Journal of Cancer, 29A, 1335–1344.
- 206 Van Poppel, G., Poulson, H.E., Loft, S. (1995). No influence of β-carotene on oxidative damage in male smokers. Journal of National Cancer Institute, 87, 310–311.
- 207 Velioglu, Y.S., Mazza, G., Gao, L., Oomah, B.D. (1998). Antioxidative activity and total phenolics in selected fruits, vegetables and grain products. Journal of Agricultural Food Chemistry, 46, 4113–4117.
- 208 Verlangieri, A.J., Kapeghian, J.C., El-Dean, S., Bush, M. (1985). Fruit and vegetable consumption and cardiovascular mortality. Medical Hypothesis, 16, 7–15.
- 209 Vinson, J.A., Hao, Y., Su, K., Zubic, L. (1998). Food antioxidant quantity and quality in foods: Vegetables. Journal of Agricultural Food Chemistry, 46, 3630–3634.
- 210 Wanasundara, U., Amarowicz, R., Sahidi, E. (1994). Isolation and identification of an antioxidative component in canola meal. Journal of Agricultural Food Chemistry, 42, 1285–1290.
- 211 Wang, H., Cao, G., Prior, R.L. (1997). Oxygen radical absorbing capacity of anthocyanin. Journal of Agricultural Food Chemistry, 45, 304–309.
- 212 Wang, H., Cao, G.H., Prior, R.L. (1996). Total antioxidant capacity of fruits. Journal of Agricultural Food Chemistry, 44, 701–705.
- 213 Wargovich, M.J. (2000). Anticancer properties of fruits and vegetables. Horticulture Science, 35, 573–575.
- 214 Wattenberg, L.W. & Coccin, J.B. (1991). Inhibition of 4-methylnitrosoamine-1-(3-pyridyl)-1-butanone carcinogenesis in mice by D-limonene and citrus fruit oils. Carcinogenesis, 12, 115–117.
- 215 Wayner, D.D.M., Burton, G.W., Ingold, K.U., Barelay, L.R.C., Locke, S.J. (1987). The relative contribution of vitamin E, urate, ascorbate, and protein to the total peroxyl radical-trapping antioxidant activity of human blood plasma. Biochimica et Biophysica Acta, 924, 408–419.
- 216 Weisburger, J.H. (1998). Evaluation of the evidence on the role of tomato products in disease prevention. Proceedings of Society for Experimental Biology and Medicine, 218, 140–143.
- 217 West, C. & Castenmiller, J. (1998). Food processing and bioavailability of food antioxidants. In: Proceedings. FAIR CT95-0158 Symposium Natul. Antioxidants in Processed Foods-Effects on storage characteristics and nutritional value. Denmark: Agril. University of Federiksberg.
- 218 Wijewickreme, A.N. & Kitts, D.D. (1998). Oxidative reactions of model Maillard reaction products and α-tocopherol in a flour-lipid mixture. Journal of Food Science, 63, 466–471.
- 219 Wijewickreme, A.N., Krejpcio, Z., Kitts, D.D. (1999). Hydroxyl scavenging activity of glucose, fructose, and ribose-lysine model Maillard products. Journal of Food Science, 64, 457–461.
- 220 Willet, C.W. (1994). Diet and health: What should we eat? Science, 264, 532–537.
- 221 Williamson, G., Faulkner, K., Plumb, G.W. (1998). Glucosinolates and phenolics as antioxidants from plant foods. European Journal of Cancer Prevention, 7, 17–21.
- 222 Yen, G.C. & Tsai, L.C. (1993). Antimutagenecity of partially fractionated Maillard Reaction Product. Food Chemistry, 47, 11–15.
- 223 Yen, G.C., Chen, H.W., Duh, P.D. (1998). Extraction and identificaion of an antioxidative component from Jue Ming Zi (Cassia tora L.). Journal of Agricultural Food Chemistry, 46, 820–824.
- 224 Yen, G.C., Wu, S.C., Duh, P.D. (1996). Extraction and identification of antioxidant components from the leaves of mulberry. Journal of Agricultural Food Chemistry, 44, 1687–1690.
- 225 Zhang, Y., Kenski, T.W., Cho, C.G., Posner, G.S., Talalay, P. (1994a). Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceeding of National Academy of Sciences, USA, 91, 2147–2150.